Allergan to buy migraine drug maker Map Pharmaceuticals









Allergan Inc., the Irvine maker of the wrinkle filler Botox, agreed to buy a Silicon Valley pharmaceutical company in a deal valued at $958 million to gain an experimental inhalable migraine treatment.


Allergan will pay Map Pharmaceuticals Inc. investors $25 a share, a 60% premium over Tuesday's closing price of $15.58 in New York, the companies said in a statement. The deal was unanimously approved by the boards of both companies and is expected to close late in the first quarter or in the second quarter, the companies said.


Allergan has targeted sales growth in specialty pharmaceuticals and skin care as it considers divesting its weight-loss unit, including the Lap-Band device, Chief Executive David Pyott has said. The company has announced five acquisitions in the last two years, including a $350-million deal in November for a unit of SkinMedica Inc.





Map, based in Mountain View, is seeking U.S. regulatory approval for Levadex, an inhaled form of a 60-year-old migraine drug, to treat those who have acute attacks.


Allergan's Botox is approved as a treatment for chronic migraine patients, those who suffer attacks more than 15 days a month. The companies agreed in January 2011 to co-promote Levadex should it gain approval.


"We plan to capitalize on this depth of expertise in neurology as we continue the global development of Levadex as a potential acute treatment for migraine that is complementary to Botox and use Map's proprietary drug particle and inhalation technologies to generate new pipeline opportunities," Pyott said in the statement.


Allergan shares gained less than 1% to close at $105.75 in New York. The shares have increased 20% in the last 12 months.


More than 36 million Americans suffer from migraines, a neurological condition that triggers headaches, dizziness, nausea and sensitivity to sound and light. The global market for migraine treatments should increase 38% to $4.4 billion from $3.2 billion in 2013, according to Burlington, Mass.-based Decision Resources. If approved, Levadex may be worth $1 billion a year by 2020, the firm said.





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In Obama's inaugural speech, a sweeping liberal vision









WASHINGTON — Allowing that "our journey is not complete," President Obama offered a robust liberal vision of America in his second inaugural address, embracing gay rights, action on climate change and a substantial role for government even as he acknowledged the challenges of a bitterly divided nation.


An ocean of American flags waved under overcast skies and hundreds of thousands of faces tilted up just before noon Monday as Obama stood on the Capitol's West Front and repeated the oath of office in America's 57th presidential inauguration.


Chants of "O-ba-ma" rose, echoing from a packed National Mall. The atmosphere was festive, but the fevered excitement that welcomed America's first African American president four years ago had been toned down. Still, though the crowd appeared smaller, it may rank as one of the largest for an inaugural celebration.





In an 18-minute speech, Obama paid tribute to the vast cultural, demographic and political changes that twice helped sweep him into office.


He also highlighted themes of national unity, borrowing language that even the most ardent tea party follower would endorse — praising "the patriots of 1776," describing freedom as "a gift from God," endorsing healthy skepticism of "central authority," and describing as "fiction" the notion that government can solve all ills.


But Obama made clear he views government as essential to fix the nation's problems and to guarantee the security of its citizens, reaffirming Democratic ideology stretching from the days of Franklin D. Roosevelt's New Deal.


"Medicare and Medicaid and Social Security, these things do not sap our initiative," he said. "They do not make us a nation of takers. They free us to take the risks that make this country great."


The remarks were an allusion to one of the fiercest arguments of the presidential campaign — when Republican nominee Mitt Romney described 47% of Americans, Obama supporters, as overly reliant on government — as well as to attacks on entitlement programs during recent budget battles in Congress.


Obama became the first president to use an inaugural address to call for an end to discrimination against gays and lesbians, equating it with landmark movements for women's suffrage and African American civil rights.


"Our journey is not complete until our gay brothers and sisters are treated like anyone else under the law," Obama said as the crowd applauded.


Obama, who long said he was evolving on same-sex marriage, waited until his reelection campaign was in full swing last year before he announced his support.


Speaking on Martin Luther King Jr. Day, a federal holiday, Obama alluded to the slain civil rights leader after putting his hand on two Bibles — one owned by King, and the other used at the 1861 inauguration of Abraham Lincoln.


Obama first took the oath of office from Chief Justice John G. Roberts Jr. at the White House on Sunday, when his term officially began. On Monday, Roberts administered the oath again, and the two men spoke slowly and carefully — unlike four years ago, when they mangled the text and had to arrange a private do-over at the White House.


Former Presidents Bill Clinton and Jimmy Carter, both Democrats, and their spouses were among the dignitaries who bundled up in heavy coats on a wintry gray morning to witness the public oath. The other living former presidents, Republicans George H.W. Bush, who was recently released from two months in the hospital, and his son, George W. Bush, were absent. Both issued warm statements of congratulations to the Obamas.


In his address, Obama offered an ideological primer on Democrats' beliefs, rather than specifics of the fights likely to dominate the upcoming session of Congress.


He cited Newtown, referring to the horrific elementary school shooting in Connecticut last month, but did not explicitly mention gun violence or firearms control.


He declared that the nation could not succeed "when a shrinking few do very well and a growing many barely make it," the kind of language that sparked Republican complaints during the presidential race that he was engaging in class warfare. But he did not say how he would rectify the disparity.


And while he emphasized the need to rise above "party or faction," he aimed a series of barely concealed zingers at his opponents, including those who deny climate change. He said failure to respond to that threat "would betray our children and future generations," but offered no clues of what he might do.


"We cannot mistake absolutism for principle," he said in another pointed passage, "or treat name-calling as reasoned debate."


Some Republicans said they searched in vain for olive branches. Sen. John McCain (R-Ariz.), who lost to Obama in 2008, said the president did not reach out to "those on the other side of the aisle in a plea to work together."





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Nearly 20,000 new BlackBerry 10 apps submitted this past weekend







Research in Motion (RIMM) held a “Port-A-Thon” earlier this month to boost developer interest in BlackBerry 10. The event ended up being a huge success for the company with more than 15,000 apps submitted to BlackBerry World in less than two days. In a last chance effort to increase its app count before the launch of its new operating system, RIM held a second event this past weekend and it was even bigger than the first one. Developers submitted 19,071 apps in 36 hours, bringing RIM closer to its goal of offering more than 70,000 apps at launch. RIM is scheduled to unveil BlackBerry 10 at a press event on January 30th.


[More from BGR: BlackBerry 10 OS walkthrough, BlackBerry Z10 pricing]






This article was originally published on BGR.com


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Beyonce, Hudson do star turns at inauguration


WASHINGTON (AP) — Beyonce drew a loud cheer at the inauguration Monday even before her impressive rendition of the national anthem. But in the role she played four years ago singing for the president and first lady at the inaugural ball was her "Dreamgirls" co-star Jennifer Hudson.


If President Barack Obama's first inaugural theme seemed to be summed up by Beyonce's "At Last," this time it was Hudson's version of Al Green's "Let's Stay Together."


Hudson was among the entertainment at Monday night's inaugural balls, joined by Stevie Wonder and Alicia Keys, who modified her hit "Girl on Fire" to sing "He's the president and he's on fire ... Obama's on fire. Obama's on fire."


The crowd at the official Inaugural Ball joined in with the Grammy-nominated fun. anthem "We Are Young."


And Wonder got small knots of dancers going with crowd-pleasers such as "Signed, Sealed, Delivered I'm Yours."


Earlier in the day, the applause for Beyonce started when she took her place with Jay-Z at the Capitol to watch President Barack Obama take the oath for his second term in office. The two stopped to chat with the Rev. Al Sharpton.


James Taylor kicked off the musical performances, strumming his guitar and singing "America the Beautiful." Kelly Clarkson followed with a different arrangement of "My Country 'Tis of Thee." Then Beyonce was introduced and the crowd again roared its approval.


Beyonce had a definite fan in Supreme Court Justice Clarence Thomas, who applauded eagerly after she finished singing the national anthem. She offered R&B-esque vocal riffs as she sang on and the crowd seemed to love it, cheering loudly as she finished. Clarkson, too, hit high notes.


Beyonce may have been the star musical attraction, but she had plenty of company from Hollywood at the Capitol on Monday. Katy Perry and John Mayer sat side-by-side, with Perry in an orange-striped coat and wide hat, and Mayer in dark sunglasses. Singer-songwriter Ke$ha was there, too.


People flocked to the colorful pop star, snapping photos. And Perry did the same, taking shots of "Girls" actress and daughter of news anchor Brian Williams, Allison Williams.


Actress Eva Longoria was seated on the platform outside the Capitol after making an appearance at a Kennedy Center performance Sunday night. Perry sang at the children's concert the night before.


Former Boston Celtics great Bill Russell was in the crowd, too, along with actor Marlon Wayans.


___


AP writers Donna Cassata, Darlene Superville, Josh Lederman and Jocelyn Noveck contributed to this report.


__


Follow Mesfin Fekadu on Twitter at http://twitter.com/MusicMesfin


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The Week: A Roundup of This Week’s Science News





“Science,” a colleague once said at a meeting, “is a mighty enterprise, which is really rather quite topical.” He was so right: as we continue to enhance our coverage of the scientific world, we always aim to keep the latest news front and center.




His observation seemed like a nice way to introduce this column, which will highlight the week’s developments in health and science news and glance at what’s ahead. This past week, for instance, the mighty enterprise of science addressed itself to such newsy topics as the flu (there’s still time to get vaccinated!), and mental illness and gun control.


In addition to the big-headline stories that invite wisdom from scientists, each week there is a drumbeat of purely scientific and medical news that emerges from academic journals, fieldwork and elsewhere. These developments, from the quirky to the abstruse, often make their way into the daily news cycle, depending on the strength of the research behind them. (Well, that’s how we judge them, anyway.)


Many discoveries are hard to unravel. “In a way, science is antithetical to everything that has to do with a newspaper,” the same colleague observed. “You couldn’t imagine anything less consumer-friendly.”


Let’s aim to fix that. Below, a selection of the week’s stories.


DEVELOPMENTS


Health


Strange, but Effective


People with a bacterial infection called Clostridium difficile — which kills 14,000 Americans a year — have a startling cure: a transplant of someone else’s feces into their digestive system, which introduces good bacteria that the gut needs to fight off the bad. For some people, antibiotics don’t fix this problem, but an infusion of diluted stool from a healthy person seems to do the trick.


Genetics


Dig We Must



Hillery Metz and Hopi Hoekstra/Harvard University



Evolutionary biologists at Harvard took a tiny species of deer mice, known for building elaborate burrows with long tunnels, and bred it with another species of deer mice, which builds short-tunneled burrows. Comparing the DNA of the original mice with their offspring, the biologists pinpointed four regions of genetic code that help tell the mice what kind of burrow to construct.


Aerospace


Launch, Then Inflate



Uncredited/Bigelow Aerospace, via Associated Press



NASA signed a contract for an inflatable space habitat — roughly pineapple-shaped, with walls of floppy cloth — that will ideally be appended to the International Space Station in 2015. NASA aims to use the pod to test inflatable technology in space, but the company that builds these things, Bigelow Aerospace, has bigger ambitions: think of a 12-person apartment and laboratory in the sky, with two months’ rent at north of $26 million.


Biology


What’s Green and Flies?



Jodi Rowley/Australian Museum



National Geographic reported on an Australian researcher working in Vietnam who discovered a great-looking new species of flying frog. Described as having flappy forearms (the better for gliding), the three-and-a-half-inch-long frog likes to “parachute” from tree to tree, Jodi Rowley, an amphibian biologist at the Australian Museum in Sydney, told the magazine. She named it Helen’s Flying Frog, for her mother.


Privacy


That’s Joe’s DNA!


People who volunteer their genetic information for the betterment of science — and are assured anonymity — may find that their privacy is not a slam dunk. A researcher who set out to crack the identities of a few men whose genomes appeared in a public database was able to do so using genealogical Web sites (where people upload parts of their genomes to try to find relatives) as well as some simple search tools. He was trying to test the database’s security, but even he did not expect it to be so easy.


Genetics


An On/Off Switch for Disease


Geneticists have long puzzled over what it is that activates a disease in one person but not in another — even in identical twins. Now researchers from Johns Hopkins and the Karolinska Institute in Sweden who studied people with rheumatoid arthritis have identified a pattern of chemical tags that tell genes whether to turn on or not. In rheumatoid arthritis, the immune system attacks the body, and it is thought the tags enable the attack.


Planetary Science


That Red Planet


Everybody loves Mars, and we’re all secretly hoping that NASA’s plucky little rover finds evidence of life there. Meanwhile, a separate NASA craft — the Mars Reconnaissance Orbiter, which has been looping the planet since 2006 — took some pictures of a huge crater that looks as if it once held a lake fed by groundwater. It is too soon to say if the lake held living things, but NASA’s news release did include the happy phrase “clues to subsurface habitability.”


COMING UP


Animal Testing


Retiring Chimps



Emily Wabitsch/European Pressphoto Agency



A lot of people have strong feelings about the use of chimpanzees in biomedical and behavioral experiments, and the National Institutes of Health has been listening. On Tuesday, the agency is to release its recommendations for curtailing chimp research in a big way. This will be but a single step in a long process and it will apply only to the chimps the agency owns, but it may well stir big reactions from many constituencies.


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Bank of Japan sets 2% inflation plan









TOKYO — Bowing to government pressure, Japan's central bank Tuesday pledged more aggressive action to boost the economy, including setting a 2% inflation target.

The Bank of Japan said it would conduct "open-ended" asset purchases to help achieve the goal of breaking out of a long spell of deflation.

Prime Minister Shinzo Abe had urged the central bank to ease monetary policy further to help the recession-struck economy escape from years of falling prices.








Whether the effort will succeed remains to be seen: the central bank has not achieved even its 1% inflation target, with price increases hovering below 0.5% for the past two years despite surges in energy costs.

The central bank described its inflation goal as a "price stability target."

"Under the price stability target, the bank will pursue monetary easing and aim to achieve this target at the earliest possible time," it said.

But it said it also would "ascertain whether there is any significant risk to the sustainability of economic growth, including from the accumulation of financial imbalances."

Among the risks are a ballooning public debt, already well over twice the size of Japan's gross domestic product.

Abe's government is seeking to spur growth both through heavy government spending on public works and other projects and through monetary easing. The announcement by the central bank Tuesday was in line with expectations.

The government was determined that the central bank set a 2% inflation target, trade minister Toshimitsu Motegi told reporters on Monday.

"We want a clear inflation target to aim for," Motegi said. "Other countries have inflation targets, and it's not just 1 percent. They are all at least 2%," he said.

Motegi said the monetary easing, which has involved tens of trillions of yen (hundreds of billions of dollars) in asset purchases and years of near-zero interest rates, so far has been "inadequate."

The Abe government is expected to nominate as Bank of Japan governor an expert known to favor its policies when the term of the current governor, Masaaki Shirakawa, ends this spring.

However, Motegi rejected accusations that the government's demands are meant to erode the central bank's independent status.

"We are not doing this to gang up and pick on Mr. Shirakawa," he said. But he said that "the policy of aiming to escape deflation will not change, not today, not tomorrow or the day after tomorrow."

Critics of the government's strategy of pushing for more inflation argue that it will do little to stimulate real demand in the economy if it pushes up prices without accompanying gains in purchasing power.





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Gun control draws vigorous debate across California









From shooting ranges to churches, gun control was the subject of vigorous debate over the weekend at various venues across California.


In Sacramento, hundreds rallied in front of the Capitol on Saturday to protest efforts to restrict gun ownership. President Obama has called for an assault weapons ban, a universal background check system for every gun sale and a ban on high-capacity ammunition magazines.


At the Los Angeles Gun Club, range master Joseph Im said the downtown facility had seen an uptick in its ammunition sales since the Sandy Hook shooting and the renewed debate over gun control.





Thomas Brambila, 38, and Tamara Vravis, 43, had come to the range on a first date. Brambila said he had grown up target shooting, although he does not own a gun now because he has young children at home. He called Obama's gun control proposal "misguided."


Vravis said she grew up on a ranch in Minnesota, where guns were common. She agreed with Brambila.


"I think if you really want to get a gun, you can get a gun. It's going to hurt the law-abiding citizens," she said of the move to tighten gun laws.


While some people were celebrating their love of guns, others held events to draw attention to gun violence. A network of churches around the country planned a Gun Violence Prevention Sabbath in response to the Sandy Hook shooting, with services centering on community members who have lost family members to gun violence.


The City of Refuge Church in Gardena held special services Sunday to call for efforts to crack down on gun violence. Hollywood Adventist Church held a smaller gathering of a few dozen Saturday.


Carmen Taylor Jones and Darryl Jones spoke about their 15-year-old daughter, Breon Taylor, who was killed five years ago Saturday when two young men shot through a window into the Lakewood Masonic Lodge, where Breon was one of several hundred young people attending a birthday party. Breon and a 17-year-old boy were killed.


It was the day before Taylor Jones' 45th birthday.


"At that moment, in the twinkling of an eye, everyone's lives, some of their destinies were interrupted," Taylor Jones said.


The gunmen who shot into the party, 16 and 19 at the time, were eventually sentenced to a combined 400 years in prison.


Taylor Jones, who grew up in Watts, said she sees memorials for other young people who were gunned down and worries about the safety of her 15-year-old son.


"When he's with me in South Los Angeles, I almost feel like he's a target, like he has a mark on him," she said.


Taylor Jones said she believes the Sandy Hook massacre got people's attention in a way that individual tragedies like her daughter's death couldn't. She called Obama's gun control proposal "a step in the right direction."


"It's just time for us to have some very serious conversations," she said.


The Sacramento protest was one of dozens held at state capitals nationwide as politicians push new gun laws.


They keep adding more and more laws," said Wes Holst, who hosts a radio show about guns in Santa Cruz. "More laws don't prevent crime."


Some people waved flags or hoisted signs saying "Hands off my guns" and "Gun laws don't stop criminals, bullets do," and many spoke fearfully of restrictions they say would leave them defenseless against criminals or even a government they view with suspicion.


California has some of the toughest gun laws in the country, and there were no firearms to be seen at Saturday's rally. A few people wore empty holsters.


Daniel Silverman, an information technology consultant who lives in Tracy, Calif., said he organized the Sacramento event as part of a grass-roots campaign called Guns Across America. He said the rally was not connected to Gun Appreciation Day, which was started by a Republican consulting firm in Washington.


He said politicians have unfairly singled out firearms as the cause of violence. A gun, he said, is only "a piece of plastic, aluminum and steel that does no harm in the hands of good men and women."


abby.sewell@latimes.com


chris.megerian@latimes.com





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RIM heats up as BlackBerry 10 launch nears







Research In Motion (RIMM) shares are soaring ahead of the imminent launch of the firm’s next-generation BlackBerry 10 platform. The stock’s recent run could come screeching to a halt at any moment as short interest grows, but Jefferies & Company analyst Peter Misek thinks there’s plenty more good news ahead for RIM. In a note to investors on Friday morning, Misek told clients to buy RIM stock and set a new 12-month price target of $ 19.50, up from his previous $ 13 target with a Hold rating.


[More from BGR: Samsung’s latest monster smartphone will reportedly have a 5.8-inch screen]






“Our checks indicate that the carriers have agreed to volume commitments for the first two quarters post-launch,” Misek wrote. He also notes that “BB10 builds have been raised from 500K/month in early Dec to 1M-2M/month,” and “Developers are supporting BB10 more than we expected. RIM is targeting 70K BB10 apps available at launch.”


[More from BGR: Cable companies called ‘monopolies that stifle competition and innovation’]


Misek says that RIM’s next-generation platform will enable secure corporate email services on iOS and Android devices and the market has overlooked this major change so far. The analyst believes RIM’s March- and August-quarter results will beat Wall Street’s current consensus now that RIM’s huge installed base will finally have a “legitimate upgrade opportunity.”


This article was originally published on BGR.com


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ABC News' Barbara Walters hospitalized after fall


NEW YORK (AP) — Veteran ABC newswoman Barbara Walters has fallen at an inauguration party at an ambassador's home in Washington and has been hospitalized.


Walters, 83, fell Saturday night on a step at the residence of Britain's ambassador to the United States, Peter Westmacott, ABC News spokesman Jeffrey Schneider said. The fall left Walters with a cut on her forehead, he said.


Walters, out of an abundance of caution, went to a hospital for treatment of the cut and for a full examination, Schneider said on Sunday. She was alert and was "telling everyone what to do, which we all take as a very positive sign," he said.


It was unclear when Walters might be released from the hospital, which ABC didn't identify.


Walters was TV news' first female superstar, making headlines in 1976 as a network anchor with an unprecedented $1 million annual salary. During more than three decades at ABC, and before that at NBC, her exclusive interviews with rulers, royalty and entertainers have brought her celebrity status. In 1997, she created "The View," a live weekday talk show that became an unexpected hit.


Walters had heart surgery in May 2010 but returned to active duty on "The View" that September, declaring, "I'm fine!"


Even in her ninth decade, Walters continues to keep a busy schedule, including appearances on "The View," prime-time interviews and her annual special, "10 Most Fascinating People," on which, in December, she asked New Jersey Gov. Chris Christie if he considered himself fit enough to be president someday. (Christie, although acknowledging he is "more than a little" overweight, replied he would be up to the job.)


Last June, Walters apologized for trying to help a former aide to Syrian President Bashar Assad land a job or get into college in the United States. She acknowledged the conflict in trying to help Sheherazad Jaafari, daughter of the Syrian ambassador to the United States and a one-time press aide to Assad. Jaafari helped Walters land an interview with the Syrian president that aired in December 2011.


Walters said she realized the help she offered Jaafari was a conflict and said, "I regret that."


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Well: A Check on Physicals

“Go Beyond Your Father’s Annual Physical. Live Longer, Feel Better”

This sales pitch for the Princeton Longevity Center’s “comprehensive exam” promises, for $5,300, to take “your health beyond the annual physical.” But it is far from certain whether this all-day checkup, and others less inclusive, make a meaningful difference to health or merely provide reassurance to the worried well.

Among physicians, researchers and insurers, there is an ongoing debate as to whether regular checkups really reduce the chances of becoming seriously ill or dying of an illness that would have been treatable had it been detected sooner.

No one questions the importance of regular exams for well babies, children and pregnant women, and the protective value of specific exams, like a Pap smear for sexually active women and a colonoscopy for people over 50. But arguments against the annual physical for all adults have been fueled by a growing number of studies that failed to find a medical benefit.

Some experts note that when something seemingly abnormal is picked up during a routine exam, the result is psychological distress for the patient, further testing that may do more harm than good, and increased medical expenses.

“Part of the problem of looking for abnormalities in perfectly well people is that rather a lot of us have them,” Dr. Margaret McCartney, a Scottish physician, wrote in The Daily Mail, a British newspaper. “Most of them won’t do us any harm.”

She cited the medical saga of Brian Mulroney, former prime minister of Canada. A CT scan performed as part of a checkup in 2005 revealed two small lumps in Mr. Mulroney’s lungs. Following surgery, he developed an inflamed pancreas, which landed him in intensive care. He spent six weeks in the hospital, then was readmitted a month later for removal of a cyst on his pancreas caused by the inflammation.

The lumps on his lungs, by the way, were benign. But what if, you may ask, Mr. Mulroney’s lumps had been cancer? Might not the discovery during a routine exam have saved his life?

Logic notwithstanding, the question of benefits versus risks from routine exams can be answered only by well-designed scientific research.

Defining the value of a routine checkup — determining who should get one and how often — is especially important now, because next year the Affordable Care Act will add some 30 million people to the roster of the medically insured, many of whom will be eligible for government-mandated preventive care through an annual exam.

Dr. Ateev Mehrotra of the University of Pittsburgh School of Medicine, who directed a study of annual physicals in 2007, reported that an estimated 44.4 million adults in the United States undergo preventive exams each year. He concluded that if every adult were to receive such an exam, the health care system would be saddled with 145 million more visits every year, consuming 41 percent of all the time primary care doctors spend with patients.

There is already a shortage of such doctors and not nearly enough other health professionals — physician assistants and nurse practitioners — to meet future needs. If you think the wait to see your doctor is too long now, you may want to stock up on some epic novels to keep you occupied in the waiting room in the future.

Few would challenge the axiom that an ounce of prevention is worth a pound of cure. Lacking incontrovertible evidence for the annual physical, this logic has long been used to justify it:

¶ If a thorough exam and conversation about your well-being alerts your doctor to a health problem that is best addressed sooner rather than later, isn’t that better than waiting until the problem becomes too troublesome to ignore?

¶ What if you have a potentially fatal ailment, like heart disease or cancer, that may otherwise be undetected until it is well advanced or incurable?

¶ And wouldn’t it help to uncover risk factors like elevated blood sugar or high cholesterol that could prevent an incipient ailment if they are reversed before causing irreparable damage?

Even if there is no direct medical benefit, many doctors say that having their patients visit once a year helps to maintain a meaningful relationship and alert doctors to changes in patients’ lives that could affect health. It is also an opportunity to give patients needed immunizations and to remind them to get their eyes, teeth and skin checked.

But the long-sacrosanct recommendation that everyone should have an annual physical was challenged yet again recently by researchers at the Nordic Cochrane Center in Copenhagen.

The research team, led by Dr. Lasse T. Krogsboll, analyzed the findings of 14 scientifically designed clinical trials of routine checkups that followed participants for up to 22 years. The team found no benefit to the risk of death or serious illness among seemingly healthy people who had general checkups, compared with people who did not. Their findings were published in November in BMJ (formerly The British Medical Journal).

In introducing their analysis, the Danish team noted that routine exams consist of “combinations of screening tests, few of which have been adequately studied in randomized trials.” Among possible harms from health checks, they listed “overdiagnosis, overtreatment, distress or injury from invasive follow-up tests, distress due to false positive test results, false reassurance due to false negative test results, adverse psychosocial effects due to labeling, and difficulties with getting insurance.”

Furthermore, they wrote, “general health checks are likely to be expensive and may result in lost opportunities to improve other areas of health care.”

In summarizing their results, the team said, “We did not find an effect on total or cause-specific mortality from general health checks in adult populations unselected for risk factors or disease. For the causes of death most likely to be influenced by health checks, cardiovascular mortality and cancer mortality, there were no reductions either.”

What, then, should people do to monitor their health?

Whenever you see your doctor, for any reason, make sure your blood pressure is checked. If a year or more has elapsed since your last blood test, get a new one.

Keep immunizations up to date, and get the screening tests specifically recommended based on your age, gender and known risk factors, including your family and personal medical history.

And if you develop a symptom, like unexplained pain, shortness of breath, digestive problems, a lump, a skin lesion that doesn’t heal, or unusual fatigue or depression, consult your doctor without delay. Seek further help if the initial diagnosis and treatment fails to bring relief.

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