Artist Christo takes small steps on Colo. project


DENVER (AP) — Construction of the proposed "Over the River" project in Colorado is on hold pending legal challenges, but artist Christo said Wednesday his team is doing other work so he can one day suspend nearly six miles worth of silvery fabric in sections over the Arkansas River.


Railroad tracks are being cleared along the project route that traces U.S. 50 between Canon City and Salida, and work is beginning to mitigate impacts to bighorn sheep.


Christo is also preparing for his upcoming exhibit in Oberhausen in Germany of "Big Air Package," a 295-foot air-filled fabric bubble that will help raise funds for Over the River, which has cost $13 million so far.


As envisioned by Christo and his late wife, Jeanne-Claude, Over the River would be displayed for two weeks in late summer. The earliest it could be displayed is August 2016, but even that timeline may be unlikely.


The Bureau of Land Management's approval of a permit for it is being appealed, and a group called Rags Over the Arkansas River has filed lawsuits challenging permit approvals by the BLM and Colorado State Parks.


Opponents contend the project poses environmental, safety, traffic and economic risks and will require more than two years of industrial-scale construction work. Christo's team has said it plans dozens of measures to mitigate impacts.


Christo and Jeanne-Claude's massive projects have survived delays before.


"I don't consider it a pause," Christo said. "It's part of the dynamics of the project."


During the work on Over the River, he also is actively working on The Mastaba, a giant sculpture of 410,000 barrels planned for Abu Dhabi that he conceived in 1977. Because he is 77, Christo said he is trying to complete both projects simultaneously rather than focusing on one at a time.


Christo was in Denver for an exhibit Wednesday at Metropolitan State University of Denver's Center for Visual Art of two sketches he donated to Colorado.


___


Find Catherine Tsai on Twitter at http://www.twitter.com/ctsai_denver


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Well: Long Term Effects on Life Expectancy From Smoking

It is often said that smoking takes years off your life, and now a new study shows just how many: Longtime smokers can expect to lose about 10 years of life expectancy.

But amid those grim findings was some good news for former smokers. Those who quit before they turn 35 can gain most if not all of that decade back, and even those who wait until middle age to kick the habit can add about five years back to their life expectancies.

“There’s the old saw that everyone knows smoking is bad for you,” said Dr. Tim McAfee of the Centers for Disease Control and Prevention. “But this paints a much more dramatic picture of the horror of smoking. These are real people that are getting 10 years of life expectancy hacked off — and that’s just on average.”

The findings were part of research, published on Wednesday in The New England Journal of Medicine, that looked at government data on more than 200,000 Americans who were followed starting in 1997. Similar studies that were done in the 1980s and the decades prior had allowed scientists to predict the impact of smoking on mortality. But since then many population trends have changed, and it was unclear whether smokers today fared differently from smokers decades ago.

Since the 1960s, the prevalence of smoking over all has declined, falling from about 40 percent to 20 percent. Today more than half of people that ever smoked have quit, allowing researchers to compare the effects of stopping at various ages.

Modern cigarettes contain less tar and medical advances have cut the rates of death from vascular disease drastically. But have smokers benefited from these advances?

Women in the 1960s, ’70s and ’80s had lower rates of mortality from smoking than men. But it was largely unknown whether this was a biological difference or merely a matter of different habits: earlier generations of women smoked fewer cigarettes and tended to take up smoking at a later age than men.

Now that smoking habits among women today are similar to those of men, would mortality rates be the same as well?

“There was a big gap in our knowledge,” said Dr. McAfee, an author of the study and the director of the C.D.C.’s Office on Smoking and Public Health.

The new research showed that in fact women are no more protected from the consequences of smoking than men. The female smokers in the study represented the first generation of American women that generally began smoking early in life and continued the habit for decades, and the impact on life span was clear. The risk of death from smoking for these women was 50 percent higher than the risk reported for women in similar studies carried out in the 1980s.

“This sort of puts the nail in the coffin around the idea that women might somehow be different or that they suffer fewer effects of smoking,” Dr. McAfee said.

It also showed that differences between smokers and the population in general are becoming more and more stark. Over the last 20 years, advances in medicine and public health have improved life expectancy for the general public, but smokers have not benefited in the same way.

“If anything, this is accentuating the difference between being a smoker and a nonsmoker,” Dr. McAfee said.

The researchers had information about the participants’ smoking histories and other details about their health and backgrounds, including diet, alcohol consumption, education levels and weight and body fat. Using records from the National Death Index, they calculated their mortality rates over time.

People who had smoked fewer than 100 cigarettes in their lifetimes were not classified as smokers. Those who had smoked at least 100 cigarettes but had not had one within five years of the time the data was collected were classified as former smokers.

Not surprisingly, the study showed that the earlier a person quit smoking, the greater the impact. People who quit between 25 and 34 years of age gained about 10 years of life compared to those who continued to smoke. But there were benefits at many ages. People who quit between 35 and 44 gained about nine years, and those who stopped between 45 and 59 gained about four to six years of life expectancy.

From a public health perspective, those numbers are striking, particularly when juxtaposed with preventive measures like blood pressure screenings, colorectal screenings and mammography, the effects of which on life expectancy are more often viewed in terms of days or months, Dr. McAfee said.

“These things are very important, but the size of the benefit pales in comparison to what you can get from stopping smoking,” he said. “The notion that you could add 10 years to your life by something as straightforward as quitting smoking is just mind boggling.”

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Apple shares tumble after relatively unimpressive earnings report









Apple Inc. may still make products customers love, but its latest earnings report appears to have broken investors' hearts.


For the third quarter in a row, Apple reported revenue and profit that were impressive by normal standards, but short of what analysts had expected. Investors reacted harshly, driving Apple's stock price down more than 10% in after-hours trading Wednesday.


If that trend holds when trading opens Thursday, Apple will have lost almost $50 billion in market value in the blink of an eye, and its stock will have given up almost all the extraordinary gains it had made in the last year. Investors' and fund managers' belief in one of the world's most widely held stocks will be severely tested in the coming days.





More fundamentally, despite upbeat talk by Apple Chief Executive Tim Cook, the performance is unlikely to quell growing worries that Apple's remarkable run of dominance might be over.


"Overall, compared to other companies, it's impressive. But for Apple's standards, it's not great," said Patrick Moorhead of Moor Insights & Strategy. "I do think this somewhat fuels the perception that Apple is slowing down a bit.... And it's driven by the fact that some of its competitors are catching up, and in some markets have already caught up."


Apple executives did their best during an hourlong conference call with analysts to project optimism and excitement about both the last quarter and the months ahead. They noted that the company had trouble meeting demand for both iPads and Macs, and could have sold many more had they been able to build enough.


They also pointed to a growing business in China and the expansion of iTunes, which is now available in 119 countries.


"Apple is in one of the most prolific periods of innovation in its history," Cook said. "We continue to believe our fundamentals, our remarkable people, our clear and focused strategy will serve us well in the coming months and years ahead."


Cook praised the record numbers posted by Apple. For the three months that ended in December, Apple said revenue increased 18% to a record $54.5 billion. Profit also set an all-time high but was up only slightly from the year-earlier quarter, rising to $13.08 billion, or $13.81 a share, from $13.06 billion, or $13.87.


Apple said it sold a record 47.8 million iPhones last quarter, up from 37 million iPhones in the same quarter of 2011. Despite that massive figure, some analysts had hoped to see stronger demand with sales exceeding 50 million.


"Meeting expectations is not enough for Apple," said Colin Gillis of BGC Financial. "So that's a little bit of a disappointment…. International sales were a little weaker than people expected. So we'll see how that shakes out."


Last quarter saw the introduction of the iPad mini, a 7.9-inch version of Apple's popular tablet computer. The Cupertino, Calif., company said it sold a total of 22.9 million iPads in the quarter, also a record, up from 15.4 million a year earlier. The company didn't break out iPad mini numbers from its total tablet sales, but Chief Financial Officer Peter Oppenheimer told analysts that the smaller version has been a hit and that the company experienced significant backlog getting the product to store shelves. The 22% lower average selling price for Apple's tablets suggests the mini has performed well but probably cannibalized some sales of its 9.7-inch version.


Historic comparisons were challenging this year because the most recent quarter had only 13 weeks, compared with 14 weeks for the same quarter of 2011.


Like many retailers and consumer electronics companies, the quarter from October to December is typically Apple's largest because of the holiday shopping season. Last year, Apple managed to stun investors by beating its own revenue estimates by more than 25% and earnings forecast by nearly 50%. That sent the stock soaring.


But even as Apple extended its lead as the world's most valuable company, and set a record in August for most valuable company ever when not adjusted for inflation, doubts began to creep into the minds of analysts and investors.


Shares have plummeted 27% in the last four months. On Wednesday, shares rose $9.24, or 1.8%, to $514.01 during regular trading.


Apple reported strong earnings in both the third and fourth quarters last year, but the numbers missed analysts' consensus estimates. Gradually, analysts began lowering their forecasts for Apple's earnings for the current fiscal year. At the same time,


Apple experienced some uncharacteristic gaffes. The new Apple Maps app that replaced Google Maps on iOS 6 devices had reliability problems, prompting a rare apology by Apple. And the iPhone 5 that went on sale in September faced long shipping delays as Apple suppliers struggled to adapt to the new, longer screen size.


The dismissal of iOS chief Scott Forstall, a favorite of the late Apple co-founder Steve Jobs, raised eyebrows. But so did a new strategy for launching products: Whereas Apple updates to products used to be few and far between, the company has lately begun increasing the number of products as well as the introduction of new versions.


The first quarter saw one of the busiest product launch cycles in the company's history. The quarter was the first full quarter of sales for the iPhone 5, a new iPod Touch and nano, the fourth iPad, a new 13-inch Retina MacBook Pro, and, of course, the first iPad mini.


Observers have pointed to this accelerated pace as an indication that Apple is facing more competitive pressure from rivals such as Samsung Electronics Co., which is now the world's biggest seller of smartphones, with its Galaxy series of phones. The concern is that the faster upgrade cycle plus the smaller iPad mini will cut into Apple's historically high profit margins.


Such fears over lower profits have also been stoked by the debate over whether Apple plans to release a cheaper iPhone aimed at capturing market share in emerging economies and the concern that Apple has not been able to strike a deal with China's largest carrier.


Now that the first-quarter numbers have been released, analysts will be busy recalibrating their projections over the next couple of days. But the focus is also likely to shift to renewed speculation about new products that investors are hoping will drive another big run for the stock.


chris.obrien@latimes.com


andrea.chang@latimes.com





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Israel elections deal a major setback to Netanyahu









JERUSALEM — Israeli voters dealt a stunning political rebuke to Prime Minister Benjamin Netanyahu, leaving parliamentary elections in a virtual tie between the right and center-left and denying him the mandate he sought to pursue hawkish policies toward Palestinian peace talks, Iran's nuclear program and construction of West Bank settlements.


Netanyahu was still regarded as the most likely candidate to form a new government after Tuesday's voting because there are few other credible figures. But the disappointing performance will require him to reach out to the center in order to form a governing coalition.


With all but votes from prisoners, military voters and some government workers counted early Wednesday, Israel's conservative and religious parties had won 60 seats in the Knesset, Israel's parliament, the same number won by centrist and left-wing parties, who were led by a surprisingly strong performance from a political newcomer, Yair Lapid.





Though the final tally could change slightly, the close race all but ensures a period of turmoil before a new government emerges, and catapults Lapid and his recently formed centrist party, Yesh Atid ("There Is a Future"), into the forefront of Israeli politics. The party formed by the charismatic former TV broadcaster won 19 seats, the second-highest number of any party.


Amid a stronger-than-expected voter turnout of 67% — up from 65% in 2009 — the conservative bloc fell five seats short of the 65 seats it amassed four years ago, while the center-left parties picked up five.


The right was led by a joint slate between Netanyahu's Likud Party and former Foreign Minister Avigdor Lieberman's nationalist Yisrael Beiteinu, which won 31 seats in the 120-member Knesset. That's far less than the combined 42 seats the two parties won four years ago when they ran separately. Based on the ratio determined in the shared slate, the results translate into about 20 seats for Likud and 11 for Yisrael Beiteinu.


Netanyahu held a slim lead as returns began to pour in Tuesday night. As the results were still being tallied, he declared victory early Wednesday and vowed to seek a broad coalition.


"I believe that the election results are an opportunity to make changes that the citizens are hoping for and that will serve all of Israel's citizens," he told supporters. "I intend to lead these changes, and to this end we must form as wide a coalition as possible."


That last part, at least, will prove true for whomever forms the next government.


Even before the tally slipped into a tie, however, Labor Party leader Shelly Yachimovich called the results a "no-confidence vote" for the prime minister, saying, "The public has said a clear 'no' to Netanyahu's policy." She also vowed to fight to replace Netanyahu in the coming days.


Her left-leaning party received 15 seats, but it was eclipsed by the surprise performance of Lapid's party, which won nearly twice as many seats as polls had predicted.


The results signal a slowdown in the rightward shift of the Israeli electorate in recent years. The conservatism has been attributed to growing pessimism by many Israelis about peace talks and by the belief that Palestinians will never accept Israel as a Jewish state. Such sentiments spread after the Palestinian uprising a decade ago, when hundreds of Israeli civilians were killed in suicide bombings.


Netanyahu's tough stance toward Palestinians and expansion of Jewish settlements on land claimed by Palestinians has tapped into such sentiments.


But critics, including centrist leaders like Lapid, say Netanyahu's policies have isolated Israel internationally and squandered a chance to reach a peace deal with Palestinian Authority President Mahmoud Abbas. Abbas has been praised as a moderate Palestinian leader who disavows violence, but he has refused to resume peace talks as long as Israel continues to build settlements on land it seized during the 1967 Middle East War.


Lapid, 49, appealed to middle-class, secular moderates, focusing his campaign on a promise to end the draft exemption that allows ultra-Orthodox young people to avoid military service and to slash government subsidies to West Bank settlers.


He also supports resuming Palestinian peace talks and opposes attacking Iran's nuclear program without American cooperation.


Though center-left leaders were pressuring Lapid to boycott a new Netanyahu government, he signaled willingness — at least when it still appeared Netanyahu would win — to join if his programs are implemented.


"What is good for Israel is not in the possession of the right and nor is it in the possession of the left," he said. "It lies in the possibility of creating here a real and decent center that listens to the other side, that knows how to engage in dialogue, that remembers that we are here together."


Netanyahu had been expected to reach out to Lapid in an effort to ensure the stability of his coalition and reduce his dependency on far-right and religious parties, such as the ultra-Orthodox Shas. The nature of a governing coalition, however, was thrown into question by the election results.


In theory, adding additional partners would make it more difficult for any single party to threaten to bring down the coalition by withdrawing, although it increases the chances of internal ideological battles.





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Recibe el Cenart el “Live Performers Meeting” del 24 al 26 de enero






México, 22 Ene. (Notimex).- Del 24 al 26 de enero en el Centro Nacional de las Artes (Cenart) se llevará a cabo el “Live Performers Meeting” (LPM), el evento más importante a nivel mundial dedicado a la manipulación y mezcla de video en tiempo real.


Mediante un comunicado de la oficina de prensa del Cenart, se informó que el encuentro incluirá otras actividades en el Centro Cultural Border y la Fundación Alumnos47.






El LPM ofrece la oportunidad de experimentar tres días de actuaciones audiovisuales, talleres, mesas redondas, muestra de productos presentados por cientos de VJs, artistas audiovisuales, profesionales de los nuevos medios y pensadores de todo el mundo.


El evento promueve la práctica de las actuaciones de video en directo, gracias a un programa rico e impredecible que busca explorar temas diferentes a través de nuevos lenguajes audiovisuales, técnicas y tecnologías.


Las atracciones principales de la edición mexicana serán una gran variedad de presentaciones audiovisuales en vivo, talleres, showcases y sesiones de Djs con Vjs, así como un concurso internacional de video jockeys.


El público interesado encontrará espectáculos que van desde el live cinema, videodanza, interacción en vivo, videoarte, mapping, instalaciones multimedia, programación, arte generativo, live coding, danza y teatro con visuales, entre otras.


El LPM empezó en Italia hace ocho años y ha reunido a más de dos mil artistas de todo el mundo en sus 11 ediciones pasadas. Más de 50 mil personas han asistido a sus actividades ya que ofrece una gran gama de talleres y showcases gratuitos para el público en general, así como algunos de paga.


En esta edición en la Ciudad de México, más de 200 artistas provenientes de Argentina, Bolivia, Brasil, Canadá, Chile, Colombia, Costa Rica, Ecuador, El Salvador, España, Estados Unidos, Francia, Italia, México, Perú, Turquía, Reino Unido, Rusia, Uruguay y Venezuela, participarán en casi 100 presentaciones y talleres.


Las presentaciones audiovisuales se realizarán del 24 al 26 de enero, en el Centro Nacional de las Artes. Éstas que van desde el video teatro a la video danza, actuaciones de live cinema, visuales y música generativa, live coding, hasta las fiestas finales animadas por DJs y VJs internacionales.


El Cenart, el Centro Cultural Border y la Fundación Alumnos47 albergarán en un horario de 10:00 a 18:00 horas talleres y presentaciones dedicados a aprender y compartir, basándose en el tema de la cultura de video en vivo.


Se explorarán las teorías de producción de contenidos y el procesamiento de imágenes, además de estudiar y experimentar con nuevas tecnologías así como desarrollar debates sobre la cultura de prácticas libres y Open Source.


NTX/LGZ/MAG


Linux/Open Source News Headlines – Yahoo! News





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Walhberg: Boy band union is strong for summer tour


NEW YORK (AP) — For Donnie Wahlberg it's not a matter of why now, rather "why not?"


The recording artist-turned-actor was referring to the news of a major tour with his New Kids on the Block, who'll be joined this summer on "The Package Tour" by 98 Degrees and Boyz II Men.


"The state of the boy band union is strong," Wahlberg joked Tuesday. "Even though technically we're not really boy bands, but we're OK with that, so we'll accept it."


The three bands sold millions of records in the 1980s and '90s and helped usher in a wave of vocal groups that continues today.


The Boston-based NKOTB formed in 1984 and amassed ten Top 20 hits. They broke up in 1994 but got back together after a 14-year hiatus. Wahlberg said he feels the break coincided with the maturation of their fan base.


"They needed time to have families and husbands and children and get jobs and live their life," Wahlberg said.


But now he sees his band's music as a complement to the fans' adult lives.


"We created an outlet for them to feel good about themselves and tap into that youthfulness that had been put to bed for a long time ... you may be 40, but the euphoria of it makes you feel 14 all over again," Wahlberg said.


The band also announced a new single, "Remix (I Like The)," which will be released Jan. 28, and a new album, "10," which is out April 2.


That music will be a bit more mature than some of the band's previous material, member Joey McIntyre said.


"It is about the decisions that a grown man makes and goes through, as opposed to singing songs like 'Popsicle,'" he said.


Nathan Morris, one of the members of Boyz II Men, known since the early 1990s for such hits as "I'll Make Love to You" and "End of the Road," said the tour is going to be all about performing.


"If the boy band thing is attached, it's wonderful, but for all of us in here, we're ready to get out there and sing and perform," he said. "That's just what we do."


Though 98 Degrees is the youngest group on the bill, it has been apart the longest, 12 years.


"So we're excited to get back together and doing what we do," member Nick Lachey said. "We feel reinvigorated by our bond and by our group, so we're very excited by that."


Wahlberg, who stars as Detective Danny Reagan on the CBS television series "Blue Bloods," about several generations of a family of New York City police officers, said the boy bands' tour, kicking off May 31 in Uncasville, Connecticut, and continuing into July with more than 30 dates, is going to be "great."


"You have three acts that have lots of records, lots of fans," he said. "Fans that are anxious to sing those records and anxious to sing other bands' records, too."


___


John Carucci covers entertainment for The Associated Press. Follow him at http://www.twitter.com/jcarucci_ap


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Well: Is There an Ideal Running Form?

In recent years, many barefoot running enthusiasts have been saying that to reduce impact forces and injury risk, runners should land near the balls of their feet, not on their heels, a running style that has been thought to mimic that of our barefoot forebears and therefore represent the most natural way to run. But a new study of barefoot tribespeople in Kenya upends those ideas and, together with several other new running-related experiments, raises tantalizing questions about just how humans really are meant to move.

For the study, published this month in the journal PLoS One, a group of evolutionary anthropologists turned to the Daasanach, a pastoral tribe living in a remote section of northern Kenya. Unlike some Kenyan tribes, the Daasanach have no tradition of competitive distance running, although they are physically active. They also have no tradition of wearing shoes.

Humans have run barefoot, of course, for millennia, since footwear is quite a recent invention, in evolutionary terms. And modern running shoes, which typically feature well-cushioned heels that are higher than the front of the shoe, are newer still, having been introduced widely in the 1970s.

The thinking behind these shoes’ design was, in part, that they should reduce injuries. When someone runs in a shoe with a built-up heel, he or she generally hits the ground first with the heel. With so much padding beneath that portion of the foot, the thinking went, pounding would be reduced and, voila, runners wouldn’t get hurt.

But, as many researchers and runners have noted, running-related injuries have remained discouragingly common, with more than half of all runners typically being felled each year.

So, some runners and scientists began to speculate a few years ago that maybe modern running shoes are themselves the problem.

Their theory was buttressed by a influential study published in 2010 in Nature, in which Harvard scientists examined the running style of some lifelong barefoot runners who also happened to be from Kenya. Those runners were part of the Kalenjin tribe, who have a long and storied history of elite distance running. Some of the fastest marathoners in the world have been Kalenjin, and many of them grew up running without shoes.

Interestingly, when the Harvard scientists had the Kalenjin runners stride over a pressure-sensing pad, they found that, as a group, they almost all struck the ground near the front of their foot. Some were so-called midfoot strikers, meaning that their toes and heels struck the ground almost simultaneously, but many were forefoot strikers, meaning that they landed near the ball of their foot.

Almost none landed first on their heels.

What the finding seemed to imply was that runners who hadn’t grown up wearing shoes deployed a noticeably different running style than people who had always worn shoes.

And from that idea, it was easy to conjecture that this style must be better for you than heel-striking, since presumably it was more natural, echoing the style that early, shoeless cavemen would have used.

But the new study finds otherwise. When the researchers had the 38 Daasanach tribespeople run unshod along a track fitted, as in the Harvard study, with a pressure plate, they found that these traditionally barefoot adults almost all landed first with their heels, especially when they were asked to run at a comfortable, distance-running pace. For the group, that pace averaged about 8 minutes per mile, and 72 percent of the volunteers struck with their heels while achieving it. Another 24 percent struck with the midfoot. Only 4 percent were forefoot strikers.

When the Daasanach volunteers were asked to sprint along the track at a much faster speed, however, more of them landed near their toes with each stride, a change in form that is very common during sprints, even in people who wear running shoes. But even then, 43 percent still struck with their heels.

This finding adds to a growing lack of certainty about what makes for ideal running form. The forefoot- and midfoot-striking Kalenjin were enviably fast; during the Harvard experiment, their average pace was less than 5 minutes per mile.

But their example hasn’t been shown to translate to other runners. In a 2012 study of more than 2,000 racers at the Milwaukee Lakefront Marathon, 94 percent struck the ground with their heels, and that included many of the frontrunners.

Nor is it clear that changing running form reduces injuries. In a study published in October scientists asked heel-striking recreational runners to temporarily switch to forefoot striking, they found that greater forces began moving through the runners’ lower backs; the pounding had migrated from the runners’ legs to their lumbar spines, and the volunteers reported that this new running form was quite uncomfortable.

But the most provocative and wide-ranging implication of the new Kenyan study is that we don’t know what is natural for human runners. If, said Kevin G. Hatala, a graduate student in evolutionary anthropology at George Washington University who led the new study, ancient humans “regularly ran fast for sustained periods of time,” like Kalenjin runners do today, then they were likely forefoot or midfoot strikers.

But if their hunts and other activities were conducted at a more sedate pace, closer to that of the Daasanach, then our ancestors were quite likely heel strikers and, if that was the case, wearing shoes and striking with your heel doesn’t necessarily represent a warped running form.

At the moment, though, such speculation is just that, Mr. Hatala said. He and his colleagues plan to collaborate with the Harvard scientists in hopes of better understanding why the various Kenyan barefoot runners move so differently and what, if anything, their contrasting styles mean for the rest of us.

“Mostly what we’ve learned” with the new study, he said, “is how much still needs to be learned.”

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Allergan to buy migraine drug maker Map Pharmaceuticals









Allergan Inc., the Irvine maker of the wrinkle filler Botox, agreed to buy a Silicon Valley pharmaceutical company in a deal valued at $958 million to gain an experimental inhalable migraine treatment.


Allergan will pay Map Pharmaceuticals Inc. investors $25 a share, a 60% premium over Tuesday's closing price of $15.58 in New York, the companies said in a statement. The deal was unanimously approved by the boards of both companies and is expected to close late in the first quarter or in the second quarter, the companies said.


Allergan has targeted sales growth in specialty pharmaceuticals and skin care as it considers divesting its weight-loss unit, including the Lap-Band device, Chief Executive David Pyott has said. The company has announced five acquisitions in the last two years, including a $350-million deal in November for a unit of SkinMedica Inc.





Map, based in Mountain View, is seeking U.S. regulatory approval for Levadex, an inhaled form of a 60-year-old migraine drug, to treat those who have acute attacks.


Allergan's Botox is approved as a treatment for chronic migraine patients, those who suffer attacks more than 15 days a month. The companies agreed in January 2011 to co-promote Levadex should it gain approval.


"We plan to capitalize on this depth of expertise in neurology as we continue the global development of Levadex as a potential acute treatment for migraine that is complementary to Botox and use Map's proprietary drug particle and inhalation technologies to generate new pipeline opportunities," Pyott said in the statement.


Allergan shares gained less than 1% to close at $105.75 in New York. The shares have increased 20% in the last 12 months.


More than 36 million Americans suffer from migraines, a neurological condition that triggers headaches, dizziness, nausea and sensitivity to sound and light. The global market for migraine treatments should increase 38% to $4.4 billion from $3.2 billion in 2013, according to Burlington, Mass.-based Decision Resources. If approved, Levadex may be worth $1 billion a year by 2020, the firm said.





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In Obama's inaugural speech, a sweeping liberal vision









WASHINGTON — Allowing that "our journey is not complete," President Obama offered a robust liberal vision of America in his second inaugural address, embracing gay rights, action on climate change and a substantial role for government even as he acknowledged the challenges of a bitterly divided nation.


An ocean of American flags waved under overcast skies and hundreds of thousands of faces tilted up just before noon Monday as Obama stood on the Capitol's West Front and repeated the oath of office in America's 57th presidential inauguration.


Chants of "O-ba-ma" rose, echoing from a packed National Mall. The atmosphere was festive, but the fevered excitement that welcomed America's first African American president four years ago had been toned down. Still, though the crowd appeared smaller, it may rank as one of the largest for an inaugural celebration.





In an 18-minute speech, Obama paid tribute to the vast cultural, demographic and political changes that twice helped sweep him into office.


He also highlighted themes of national unity, borrowing language that even the most ardent tea party follower would endorse — praising "the patriots of 1776," describing freedom as "a gift from God," endorsing healthy skepticism of "central authority," and describing as "fiction" the notion that government can solve all ills.


But Obama made clear he views government as essential to fix the nation's problems and to guarantee the security of its citizens, reaffirming Democratic ideology stretching from the days of Franklin D. Roosevelt's New Deal.


"Medicare and Medicaid and Social Security, these things do not sap our initiative," he said. "They do not make us a nation of takers. They free us to take the risks that make this country great."


The remarks were an allusion to one of the fiercest arguments of the presidential campaign — when Republican nominee Mitt Romney described 47% of Americans, Obama supporters, as overly reliant on government — as well as to attacks on entitlement programs during recent budget battles in Congress.


Obama became the first president to use an inaugural address to call for an end to discrimination against gays and lesbians, equating it with landmark movements for women's suffrage and African American civil rights.


"Our journey is not complete until our gay brothers and sisters are treated like anyone else under the law," Obama said as the crowd applauded.


Obama, who long said he was evolving on same-sex marriage, waited until his reelection campaign was in full swing last year before he announced his support.


Speaking on Martin Luther King Jr. Day, a federal holiday, Obama alluded to the slain civil rights leader after putting his hand on two Bibles — one owned by King, and the other used at the 1861 inauguration of Abraham Lincoln.


Obama first took the oath of office from Chief Justice John G. Roberts Jr. at the White House on Sunday, when his term officially began. On Monday, Roberts administered the oath again, and the two men spoke slowly and carefully — unlike four years ago, when they mangled the text and had to arrange a private do-over at the White House.


Former Presidents Bill Clinton and Jimmy Carter, both Democrats, and their spouses were among the dignitaries who bundled up in heavy coats on a wintry gray morning to witness the public oath. The other living former presidents, Republicans George H.W. Bush, who was recently released from two months in the hospital, and his son, George W. Bush, were absent. Both issued warm statements of congratulations to the Obamas.


In his address, Obama offered an ideological primer on Democrats' beliefs, rather than specifics of the fights likely to dominate the upcoming session of Congress.


He cited Newtown, referring to the horrific elementary school shooting in Connecticut last month, but did not explicitly mention gun violence or firearms control.


He declared that the nation could not succeed "when a shrinking few do very well and a growing many barely make it," the kind of language that sparked Republican complaints during the presidential race that he was engaging in class warfare. But he did not say how he would rectify the disparity.


And while he emphasized the need to rise above "party or faction," he aimed a series of barely concealed zingers at his opponents, including those who deny climate change. He said failure to respond to that threat "would betray our children and future generations," but offered no clues of what he might do.


"We cannot mistake absolutism for principle," he said in another pointed passage, "or treat name-calling as reasoned debate."


Some Republicans said they searched in vain for olive branches. Sen. John McCain (R-Ariz.), who lost to Obama in 2008, said the president did not reach out to "those on the other side of the aisle in a plea to work together."





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Nearly 20,000 new BlackBerry 10 apps submitted this past weekend







Research in Motion (RIMM) held a “Port-A-Thon” earlier this month to boost developer interest in BlackBerry 10. The event ended up being a huge success for the company with more than 15,000 apps submitted to BlackBerry World in less than two days. In a last chance effort to increase its app count before the launch of its new operating system, RIM held a second event this past weekend and it was even bigger than the first one. Developers submitted 19,071 apps in 36 hours, bringing RIM closer to its goal of offering more than 70,000 apps at launch. RIM is scheduled to unveil BlackBerry 10 at a press event on January 30th.


[More from BGR: BlackBerry 10 OS walkthrough, BlackBerry Z10 pricing]






This article was originally published on BGR.com


Gadgets News Headlines – Yahoo! News





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